Side effects

Depo-Provera injection side effects

2.9

195 reviews

What Lowdown reviewers say

Data is taken from self reported Lowdown user reviews

29% no impact on mood

69% stopped periods

56% lost sex drive

48% gained weight

57% no impact on skin

Cycle return

38% don’t know impact

Depo-Provera injection

Depo-Provera injection common side effects

Data is taken from self reported Lowdown user reviews

41% of Depo-Provera injection reviewers reported vaginal dryness

39% of Depo-Provera injection reviewers reported tender breasts

34% of Depo-Provera injection reviewers reported vaginal discharge

30% of Depo-Provera injection reviewers reported lower back pain

29% of Depo-Provera injection reviewers reported sweating more than usual


Data is taken from self reported Lowdown user reviews


Reviews

2.9

195 reviews

Filter reviews

Community reviews

Injection  
Used for 18 mo - 3 yr
25 years old
🇬🇧 UK
  •  11th Oct 25

Depo-Provera injection  

Depo-Provera was great for me and it stopped my periods completely. I liked not having to take a pill everyday and I didn't want to get another copper coil so this worked well for me. However after being on it for quite a while I got unlucky and ended up with an abscess at the injection site which eventually had to be operated on, however this could have happened with any kind of injection and was just bad luck. I have since switched to Sayana Press so that I can do my own injections at home and clean the injection site beforehand to prevent another abscess.

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Top side effects not reported

0 helpful

0 comments

Injection  
Used for 3 - 6 mo
28 years old
🇬🇧 UK
  •  6th Oct 25

Depo-Provera injection  

Worst experience I’ve ever had. Since taking this I’ve felt constantly irritated, had complete lack of concentration and it’s completely wiped out my sex drive. I have now been bleeding for 2 months with no break. I have never regretted taking something so much it’s honestly made me miserable.


Very negative mood

1 more effect

0 helpful

0 comments

Injection  
Used for 1 - 3 mo
32 years old
🇬🇧 UK
  •  28th Aug 25

Depo-Provera injection  

I’ve used it on an off for years sudden lost of weight within a month since using it again.


Very positive mood

2 more effects

0 helpful

0 comments

Injection  
Used for 1 - 3 mo
34 years old
🇬🇧 UK
  •  6th Jul 25

Depo-Provera injection  

All women should really do the research before starting this medication. I have read quite a few stories online of women who have felt the same. I have basically felt like a completely different person. I am near on the end of one injection and I will not be going back for another. It’s absolutely ruined my relationship with my partner. I’ve been absolutely horrible to him and it’s only now I’m starting to realise just what this injection did to me. Thank goodness he’s so understanding and helped me through it because I was literally horrendous. Literally a few days after I had it I was a different person, I hated him. Everything he done annoyed me, I was rude and hurtful and I couldn’t control it. I would snap in and out of moods so badly that we named the other “person” Patrica. He was constantly walking on egg shells as he never knew which version he would get. I am so upset that I have felt this way in the last few months. So much so I was having suicidal thoughts. I pray that anyone doesn’t risk it because it’s been 3 months of hell for us.


Very negative mood

2 more effects

0 helpful

0 comments

Injection  
Used for 18 mo - 3 yr
25 years old
🇬🇧 UK
  •  3rd Jul 25

Depo-Provera injection  

This has been great for me helped regulate my moods no longer huge crashes i get around periods. Also it has completely stopped my periods which were heavy and painful, I get the occasional period pain leading up to when my injection is due but they are very very mild and don’t really effect me.


Very positive mood

1 more effect

0 helpful

0 comments

Injection  
Used for 1 - 3 mo
27 years old
🇬🇧 UK
  •  26th Jun 25

Depo-Provera injection  

Things I’ve had history struggling with in the past: depression, anxiety, weight Things depo increased: depression, anxiety, weight


Very negative mood

1 more effect

0 helpful

0 comments

Injection  
Used for 1 - 3 mo
27 years old
🇬🇧 UK
  •  2nd May 25

Depo-Provera injection  

Worst decision I’ve ever made Gained a lot of weight Depressed Anxious Moods all over the place


Very negative mood

2 more effects

1 helpful

0 comments

Injection  
Used for 1 - 3 mo
16 years old
🇬🇧 UK
  •  21st Mar 25

Depo-Provera injection  

This is pretty good for preventing pregnancy and my periods are thankfully gone, but now I have acne after having years of clear skin. It’s hormonal acne too due to the progesterone in the injection, so a nightmare to get rid of. I was prewarned about this issue but still hate it. I feel like my mood has gone lower too and I am more irritable than usual. Unsure whether I’ll get it again I will probably go back to the Lucette pill as that completely cleared my skin.


Somewhat negative mood

1 more effect

0 helpful

0 comments

Injection  
Used for 5 - 8 yr
31 years old
🇬🇧 UK
  •  17th Dec 24

Depo-Provera injection  

Great that it stopped my period completely, only have to remember to have it every 12 weeks


Somewhat negative mood

1 more effect

1 helpful

0 comments

Injection  
Used for 1 - 3 mo
35 years old
🇬🇧 UK
  •  9th Dec 24

Depo-Provera injection  

I’ve only had the injection once and had to come off, I already suffer mental health for years and the depo made my anxiety worse, constant bloated, the bleeding never stopped which led me to constant itch down below due to wearing constant pads, my hair was falling out so so badly, now my baby hairs are growing through and I look awful, not like my self asteem is poor already,


Very negative mood

2 more effects

1 helpful

0 comments

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