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I am 54 and towards end of perimenopause, my only way of knowing this is because I have had 2 periods in the last year. Around 47-50 I had symptoms of joint pain and severe depression, which I now realise was peri menopause( at the time GP treated individually) at 50 immediate insomnia, period every other month, hot sweats, low mood and started HRT oedtrogel pump X3 and utrogestan, I took it for 18 months, sweats stopped but low mood continued - I had no happy high even with oedtrogel increase, continued with period pain, severe itchy dry vulva and insomnia. decided that solving only 1 symptom didn't warrant staying on the HRT. I came off easily and flushes stayed away. over the span of year and a half , over span of year and half I went back to GP to focus on trying to manage severe vulva dryness and itching, change in labia shape and colour changes with no joy. I tried different topical estrogen vaginal creams, both increased a noticeable aggressive mood change. Then I gave up and found various alternatives for itchy vulva which intermittently help but still have to manage. now at 54 , hot flushes have come back during the night and new shock of finding sex painful so Google suggests vaginal atrophy- ooh happy days. It seems a continual quest just to feel okay is relentless. Currently thinking HRT again for osteoporosis but only when periods are clear of a year, the thought of a coil with vaginal atrophy makes me feel sick. In the meantime what does seem to work are supplements recommended by nutritionist for mood and mental calmness and sleep. I will ask GP to try different vaginal oesteigen to help vaginal atrophy. I will ride the hot flushes out. For the most part of my mid life has been managing symptoms.

Tibolone is a life saver, health recovering, confidence boosting and energetic. I told the GP I was progesterone intolerant, it makes me feel suicidal. She told me that doesn't happen in menopause. I tried her HRT with the supposed very low dose progestins, came close to killing myself. After trying three more with the same result, I refused to endure more of it. The GP said tough, if that's your attitude, no HRT for you. I pestered them until a locum gave me Tibolone to make me go away, it did, I'm still taking it and I've not been back in over a year to bother them!

Nothing to tell

My experience with HRT has on the whole, been positive. Over the years I have been on several different forms and will hopefully review them all

TAH BSO Oct ‘22 Started on 50 Evorel patches Upped to 75 Not absorbing Moved to gel, stated on 4 pumps per day, reduced to 2 pumps daily Blood tests Nov ‘24 No libido Low oestrogen results Upped to 100 Evorel patches

Since I have been using Blissel gel which is only a month ago I have had two water infections and discomfort

I keep taking it as I think it must be helping. However, I still have night sweats and issues sleeping. However, I know that it must be helping by topping up my estrogen

Localised HRT has helped me with some symptoms but I only used it late in my journey, I wish I’d used it sooner.

I cannot find information that really explains which hormone - ie estrogen or progesterone is causing my problems

My experience with Evorel Sequi over 8 months was that it made a very slight improvement to my brain fog and feeling slightly more like myself. The patch irritated my skin and hurt quite a lot. I continued to feel wiped out most of the time and anxious and low. I'm now trying a different HRT.

I’ve taken this HRT for 13 years I wonder if there is any other option moving forward What are the side effects of long term use

Having had a hysterectomy when I was 26. I thought my hormones would of been addressed by the NHS sooner than when I got to be in my 50s. By this point I'd gone from a happy, sharp, sexually active lady into a shell of myself who can honestly say I have not one bit of interest in the opposite sex. I'm tired all the time, Forgetful, my body aches. There is no help for the GPS, as none of them think these are medical issues. It's about time womens testosterone levels along with other hormone levels are checked routinely. Can't see this happening anytime soon. Us older ladies need help to feel alive again.

I started on Evorel Sequei, this suited me but my GP said I should change to Evorel Conti and POP contraceptive. Since I started this regime I have had regular periods. It has only been three months so I am persevering. I have irritability and anxiety, but only when I am on a period. I am a nurse and I know that many woman have a horrible time, so I don’t want to change even though it’s not perfect.

I'm definitely less psychotic coming up to the start of my period. I have a reduction in moodiness and irrational reactions. I've suffered with depression for a number of years. This is the same.

Reduced anxiety, depression and irregular heart rate

Perimenopause crept up on me and with onset of depression and weight gain with Mirena I felt older than my years. I thought my 40s would be my years after bringing up young children and the awful symptoms of Perimenopause came as a shock. I'm so pleased I went to GP and requested HRT (oestrogel). After a few weeks my skin looks radiant, my mood is sunnier and I'm beginning to get my health back. Don't suffer with debilitating Perimenopause symptoms. There's a snake oil industry of tonics and tablets which can dazzle women and not all of these are evidence based. Consider HRT its effective with positive health effects.

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My experience has been very positive with HRT.before I started using it I was losing complete control over. My bladder and the hot flushes were happening all too often. Both of these symptoms have been practically solved although in the combined pull I’ve noticed weaker bladder in the days using both hormones.

Was doing well on HRT however when my mood felt flat I upped my dose of estrogel and had bad vertigo. This could have been completely unreleased however I panicked and came off HRT. Then had an avalanche of peri symptoms so am considering going back on it with a lower dose. The worst symptoms without the hrt are the anxiety, brain fog, broken sleep, mood wings and more recently migraines. Never suffered with headaches before.

Confident it’s helping altho considering asking about increase in oestrogen as mood swings are leaving me feeling not like me