Sayana Press injection vs Depo-Provera injection
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Overview
Rated 2.9
80 reviews
Every 3 months
Frequency
94% - 99+%
Effectiveness
None
Blood clot risk
Short term
Effect on fertility
Rated 2.9
194 reviews
Every 3 months
Frequency
94% - 99+%
Effectiveness
None
Blood clot risk
Short term
Effect on fertility
What Lowdown reviewers say
Benefits: What this contraceptive can help with
Endometriosis
Heavy periods
Period pain
Endometriosis
Heavy periods
Period pain
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Check out our latest reviews
Real life reviews from people like you
Sayana Press injection reviews
80 reviews
Used for 6 - 12 mo
19 years old
🇬🇧 UK
• 26th Aug 25
Somewhat positive mood
3 more effects
0 helpful
0 comments
Used for 8+ yr
30 years old
🇬🇧 UK
• 28th May 25
Used for over 10 years, completely stopped my periods which was fantastic. The devices became harder and harder to use, needing a lot of force to inject so I ended up turning myself into a pin cushion & wasting a few, which made reordering a faff. Don’t think I gained weight and if anything my skin improved (but that could just be normal from teenage to late 20s). The only negative I noticed was decreased sex drive - but it didn’t totally go so not a massive issue for me.
Improved skin
1 more effect
0 helpful
0 comments
Used for 18 mo - 3 yr
16 years old
🇬🇧 UK
• 13th May 25
I was on this injection for 2 years, the whole process put me off . when i started the injection i had a period of 16 days (over two weeks) and it was so heavy, months went on and my periods stopped all together, i didn’t have a period for minus 2 years , i’m now on the combined pill but i did receive higher anxiety and depression towards taking it for ages, the doctor offered me antidepressants but i didn’t want to be taking them as i am a quite smily happy person but i literally lost all my energy and motivation to do anything.
Somewhat negative mood
3 more effects
0 helpful
0 comments
Used for 6 - 12 mo
19 years old
🇬🇧 UK
• 26th Aug 25
Somewhat positive mood
3 more effects
0 helpful
0 comments
Used for 8+ yr
30 years old
🇬🇧 UK
• 28th May 25
Used for over 10 years, completely stopped my periods which was fantastic. The devices became harder and harder to use, needing a lot of force to inject so I ended up turning myself into a pin cushion & wasting a few, which made reordering a faff. Don’t think I gained weight and if anything my skin improved (but that could just be normal from teenage to late 20s). The only negative I noticed was decreased sex drive - but it didn’t totally go so not a massive issue for me.
Improved skin
1 more effect
0 helpful
0 comments
Used for 18 mo - 3 yr
16 years old
🇬🇧 UK
• 13th May 25
I was on this injection for 2 years, the whole process put me off . when i started the injection i had a period of 16 days (over two weeks) and it was so heavy, months went on and my periods stopped all together, i didn’t have a period for minus 2 years , i’m now on the combined pill but i did receive higher anxiety and depression towards taking it for ages, the doctor offered me antidepressants but i didn’t want to be taking them as i am a quite smily happy person but i literally lost all my energy and motivation to do anything.
Somewhat negative mood
3 more effects
0 helpful
0 comments
Depo-Provera injection reviews
194 reviews
Used for 3 - 6 mo
28 years old
🇬🇧 UK
• 2 days ago
Worst experience I’ve ever had. Since taking this I’ve felt constantly irritated, had complete lack of concentration and it’s completely wiped out my sex drive. I have now been bleeding for 2 months with no break. I have never regretted taking something so much it’s honestly made me miserable.
Very negative mood
1 more effect
0 helpful
0 comments
Used for 1 - 3 mo
32 years old
🇬🇧 UK
• 28th Aug 25
I’ve used it on an off for years sudden lost of weight within a month since using it again.
Very positive mood
2 more effects
0 helpful
0 comments
Used for 1 - 3 mo
34 years old
🇬🇧 UK
• 6th Jul 25
All women should really do the research before starting this medication. I have read quite a few stories online of women who have felt the same. I have basically felt like a completely different person. I am near on the end of one injection and I will not be going back for another. It’s absolutely ruined my relationship with my partner. I’ve been absolutely horrible to him and it’s only now I’m starting to realise just what this injection did to me. Thank goodness he’s so understanding and helped me through it because I was literally horrendous. Literally a few days after I had it I was a different person, I hated him. Everything he done annoyed me, I was rude and hurtful and I couldn’t control it. I would snap in and out of moods so badly that we named the other “person” Patrica. He was constantly walking on egg shells as he never knew which version he would get. I am so upset that I have felt this way in the last few months. So much so I was having suicidal thoughts. I pray that anyone doesn’t risk it because it’s been 3 months of hell for us.
Very negative mood
2 more effects
0 helpful
0 comments
Used for 3 - 6 mo
28 years old
🇬🇧 UK
• 2 days ago
Worst experience I’ve ever had. Since taking this I’ve felt constantly irritated, had complete lack of concentration and it’s completely wiped out my sex drive. I have now been bleeding for 2 months with no break. I have never regretted taking something so much it’s honestly made me miserable.
Very negative mood
1 more effect
0 helpful
0 comments
Used for 1 - 3 mo
32 years old
🇬🇧 UK
• 28th Aug 25
I’ve used it on an off for years sudden lost of weight within a month since using it again.
Very positive mood
2 more effects
0 helpful
0 comments
Used for 1 - 3 mo
34 years old
🇬🇧 UK
• 6th Jul 25
All women should really do the research before starting this medication. I have read quite a few stories online of women who have felt the same. I have basically felt like a completely different person. I am near on the end of one injection and I will not be going back for another. It’s absolutely ruined my relationship with my partner. I’ve been absolutely horrible to him and it’s only now I’m starting to realise just what this injection did to me. Thank goodness he’s so understanding and helped me through it because I was literally horrendous. Literally a few days after I had it I was a different person, I hated him. Everything he done annoyed me, I was rude and hurtful and I couldn’t control it. I would snap in and out of moods so badly that we named the other “person” Patrica. He was constantly walking on egg shells as he never knew which version he would get. I am so upset that I have felt this way in the last few months. So much so I was having suicidal thoughts. I pray that anyone doesn’t risk it because it’s been 3 months of hell for us.
Very negative mood
2 more effects
0 helpful
0 comments
Used for 18 mo - 3 yr
25 years old
🇬🇧 UK
• 3rd Jul 25
This has been great for me helped regulate my moods no longer huge crashes i get around periods. Also it has completely stopped my periods which were heavy and painful, I get the occasional period pain leading up to when my injection is due but they are very very mild and don’t really effect me.
Very positive mood
1 more effect
0 helpful
0 comments
Used for 1 - 3 mo
27 years old
🇬🇧 UK
• 26th Jun 25
Things I’ve had history struggling with in the past: depression, anxiety, weight Things depo increased: depression, anxiety, weight
Very negative mood
1 more effect
0 helpful
0 comments
Used for 1 - 3 mo
27 years old
🇬🇧 UK
• 2nd May 25
Worst decision I’ve ever made Gained a lot of weight Depressed Anxious Moods all over the place
Very negative mood
2 more effects
1 helpful
0 comments
Used for 1 - 3 mo
16 years old
🇬🇧 UK
• 21st Mar 25
This is pretty good for preventing pregnancy and my periods are thankfully gone, but now I have acne after having years of clear skin. It’s hormonal acne too due to the progesterone in the injection, so a nightmare to get rid of. I was prewarned about this issue but still hate it. I feel like my mood has gone lower too and I am more irritable than usual. Unsure whether I’ll get it again I will probably go back to the Lucette pill as that completely cleared my skin.
Somewhat negative mood
1 more effect
0 helpful
0 comments
Used for 5 - 8 yr
31 years old
🇬🇧 UK
• 17th Dec 24
Great that it stopped my period completely, only have to remember to have it every 12 weeks
Somewhat negative mood
1 more effect
1 helpful
0 comments
Used for 1 - 3 mo
35 years old
🇬🇧 UK
• 9th Dec 24
I’ve only had the injection once and had to come off, I already suffer mental health for years and the depo made my anxiety worse, constant bloated, the bleeding never stopped which led me to constant itch down below due to wearing constant pads, my hair was falling out so so badly, now my baby hairs are growing through and I look awful, not like my self asteem is poor already,
Very negative mood
2 more effects
1 helpful
0 comments
Used for 18 mo - 3 yr
Lowdown user
🇬🇧 UK
• 12th Nov 24
I’ve had a really positive experience with depo. I was on it for around 4 years pre-covid, and have currently been using again for 18 months. Periods have completely stopped and I haven’t experienced side effects (my hair might be slightly thinner, but I’m not sure if I’d just never noticed I have thin hair). After stopping use the first time it did take many months for my periods to return. I’m only thinking about stopping taking it now with the recent studies on links to brain tumours.
Top side effects not reported
0 helpful
0 comments

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