Zelleta pill vs Desogestrel pill

Need help choosing? Speak to a doctor
Zelleta pill

£From £0.20/day

Desogestrel pill

£From £0.20/day

Overview

Rated 3.5

13 reviews

Daily

Frequency

93% - 99+%

Effectiveness

None

Blood clot risk

None

Effect on fertility

Rated 2.6

368 reviews

Daily

Frequency

91% - 99+%

Effectiveness

None

Blood clot risk

None

Effect on fertility

Zelleta pill ingredients

Main hormones in Zelleta pill

Less-Androgenic progestogen


Desogestrel pill ingredients

Main hormones in Desogestrel pill

Less-Androgenic progestogen

What Lowdown reviewers say

23% somewhat positive

46% spotting

46% no impact

31% lost weight

46% worse skin

Cycle return

100% don’t know impact

34% somewhat negative

43% stopped periods

54% lost sex drive

43% no impact

45% no impact on skin

Cycle return

40% don’t know impact

Benefits: What this contraceptive can help with

Period pain

Period pain

Try it now

£From £0.20/day

Try it now

£From £0.20/day

Check out our latest reviews

Real life reviews from people like you

Zelleta pill reviews

13 reviews

Progestogen-only / Mini pill  
Used for 1 - 3 mo
23 years old
🇬🇧 UK
  •  3 weeks ago

Zelleta pill  

I started this pill after being on the implant for years. I was initially scared, but this is not very different from the implant. The first six or so months are MUCH easier than when I was on the implant. I feel much more emotionally stable, with an increased libido compared to my old BC method. I like the flexibility of being able to stop taking it when I want. I take it at night which helps regulate my emotions and I feel more chilled out on this pill (I have severe anxiety). I've had no periods at all on this pill. The only downside is remembering to take it but for me the flexibility is worth it. I've also noticed more sweating and I get quite hot.

Read more

Somewhat positive mood

0 helpful

0 comments

Progestogen-only / Mini pill  
Used for 1 - 3 mo
Lowdown user
🇬🇧 UK
  •  29th Nov 24

Zelleta pill  

I have only been taking this pill for just over a month, but so far I am really happy with it. No change in moods, sex drive or skin. My boobs have grown lot - which I'm not mad about! Although I do feel slightly frumpy, as though I have put on a bit of weight - but it isn't hugely noticeable I don't think. I did have spotting for the first 2.5 weeks of using the pill which has now stopped completely.


Gained weight

1 helpful

0 comments

Progestogen-only / Mini pill  
Used for 1 - 3 mo
Lowdown user
🇬🇧 UK
  •  13th May 24

Zelleta pill  

Overall, I was happy with this pill. I am not currently on it as I'm in between prescriptions and its been difficult contacting my doctor. However, the last week without it has made me realise how I was benefitting from it. I used to get mood swings quite often which disappeared when on this pill. The first month, my mood swings were still there like before and I found that I was more likely to cry over small things but this went away after the first 4 weeks. Before, I would also get medium pain cramps that lasted nearly the whole day for about 2 weeks on and off every month. This went down to small cramps for an hour maybe one or twice a month which was definitely a positive. I did get one or two more spots on my face which was annoying as I've struggled with my skin for a while and was finally starting to clear it up before starting the pill but this wasn't a significant impact because I was used to my stubborn skin. I also got spots on my back and chest, but these started going away again after about 6-8 weeks. The main impact I had was my period. It went from being pretty regular and heavy for 6-7 days every month to a very light period (ranging from light/medium to basically only spotting) that lasted for 3 weeks. Although without cramps and because it was so light it didn't impact me much (it was more an inconvenience). After this, I wouldn't get my period for over a month (about 5 weeks) and then it started again. I understand that this is what would put most people off getting the pill and it was what I had been dreading the most but I realised that it wasn't as bad as I thought as most days I could get away with just a panty liner rather than an actual pad or tampon (and it reassured me I wasn't pregnant).


Somewhat positive mood

2 more effects

0 helpful

0 comments

Progestogen-only / Mini pill  
Used for 1 - 3 mo
23 years old
🇬🇧 UK
  •  3 weeks ago

Zelleta pill  

I started this pill after being on the implant for years. I was initially scared, but this is not very different from the implant. The first six or so months are MUCH easier than when I was on the implant. I feel much more emotionally stable, with an increased libido compared to my old BC method. I like the flexibility of being able to stop taking it when I want. I take it at night which helps regulate my emotions and I feel more chilled out on this pill (I have severe anxiety). I've had no periods at all on this pill. The only downside is remembering to take it but for me the flexibility is worth it. I've also noticed more sweating and I get quite hot.


Somewhat positive mood

0 helpful

0 comments

Progestogen-only / Mini pill  
Used for 1 - 3 mo
Lowdown user
🇬🇧 UK
  •  29th Nov 24

Zelleta pill  

I have only been taking this pill for just over a month, but so far I am really happy with it. No change in moods, sex drive or skin. My boobs have grown lot - which I'm not mad about! Although I do feel slightly frumpy, as though I have put on a bit of weight - but it isn't hugely noticeable I don't think. I did have spotting for the first 2.5 weeks of using the pill which has now stopped completely.


Gained weight

1 helpful

0 comments

Progestogen-only / Mini pill  
Used for 1 - 3 mo
Lowdown user
🇬🇧 UK
  •  13th May 24

Zelleta pill  

Overall, I was happy with this pill. I am not currently on it as I'm in between prescriptions and its been difficult contacting my doctor. However, the last week without it has made me realise how I was benefitting from it. I used to get mood swings quite often which disappeared when on this pill. The first month, my mood swings were still there like before and I found that I was more likely to cry over small things but this went away after the first 4 weeks. Before, I would also get medium pain cramps that lasted nearly the whole day for about 2 weeks on and off every month. This went down to small cramps for an hour maybe one or twice a month which was definitely a positive. I did get one or two more spots on my face which was annoying as I've struggled with my skin for a while and was finally starting to clear it up before starting the pill but this wasn't a significant impact because I was used to my stubborn skin. I also got spots on my back and chest, but these started going away again after about 6-8 weeks. The main impact I had was my period. It went from being pretty regular and heavy for 6-7 days every month to a very light period (ranging from light/medium to basically only spotting) that lasted for 3 weeks. Although without cramps and because it was so light it didn't impact me much (it was more an inconvenience). After this, I wouldn't get my period for over a month (about 5 weeks) and then it started again. I understand that this is what would put most people off getting the pill and it was what I had been dreading the most but I realised that it wasn't as bad as I thought as most days I could get away with just a panty liner rather than an actual pad or tampon (and it reassured me I wasn't pregnant).


Somewhat positive mood

2 more effects

0 helpful

0 comments


Desogestrel pill reviews

368 reviews

Progestogen-only / Mini pill  
Used for 1 - 3 mo
24 years old
🇬🇧 UK
  •  1 day ago

Desogestrel pill  

Day 1 - (14/10/24)- cramping in uterus but not like period cramps, felt more like movement down there. Day 2 - similar cramping to day 1. Day 3 - Similar cramping still (but less frequent/not as bad), increased discharge, slight pressure headache. Day 4 - Similar headache to previous day, increased discharge - no cramping at all. Day 5 - Headache on right side of head near the back (dull ache, like I was trying to fight off a migraine from starting) felt a bit spacey all day. Nausea and some different cramping to what I felt previously (like the warning sign period cramps I get before the big ones kick in) Day 6 - Same headache, nausea and spacey-ness. Found that I felt better after eating more frequently (which might make sense as to why people say they gain weight on the pill because if eating makes me feel better then I’m sure as hell going to do it) In the morning had similar cramps to day 5 but gone by evening. - Did spend the daytime out though so the headache could have been made worse by the fact I wasn’t drinking water as regularly as I usually would. Day 7 - Started the day without a headache but by lunchtime I had one again. This could be because I’d had a busy morning though and ate lunch later than usual. # Day 8 - Ok for most of the day but by the evening I felt so nauseous and headachey Day 9 - Felt down and low all day - boobs seem to hurt and feel bigger almost? Slight cramping. Day 10 - Really really low today - sore boobs Day 11 - Really sore boobs are cramping Day 17 - (30/10/24) - Been fine for most this week except I’ve had sore boobs. Yesterday I had a suspicious cramp and today I’ve had more and some spotting/pre-period blood. This would mean my period is starting on day 27/28 of my cycle not day 31-35 as usual. Day 18 - Period started, has a different consistency than usual. More mucusy? I’m really not sure how to describe it, slippery? I mean it makes sense since desogestrel thickens the mucus lining. Period cramps HURT and some clotting which I haven’t had for a couple of years. Nothing major though. Day 19 - Same as yesterday. Not an extremely heavy period where I’m constantly having to change pads but I can tell this is heavy. Still that new consistency but occasionally the usual consistency. Not as bloody as usual. Day 20 - (2/11/24) - Medium-light flow. Usual consistency like I would be coming towards the endings of my usual period. (which usually lasts about 5 days) 4/12/24 - Not sure what to say the day is. I’ve had a lot of spotting this past month and basically haven’t been a day without wearing a period pad just in case.I had a mini proper period (not spotting) last week and I’m having another proper period now. It’s a lot and I just want to be able to not wear a pad anymore. I’m going to go back to the doctor this week to tell them about what's happening and get another prescription. 21/01/24 - I have no idea what day this would be now. (I’m into my 2nd week of my 4th month) I’ve been pretty much consistently bleeding all of December. Very light with a heavier week but not like my usual period and not the same cramping/minimal cramping. I think I’ve possibly gone 2 days without wearing a pad since I last wrote. However, I did completely stop bleeding for about 3 days last week which was lovely but then I had a proper period with cramps that hurt (well more like my periods pre-pill) It seems to be slowly stopping now though. I’ve gained a bit of weight (but not gone up a dress size) but this could be because I have been less active recently and my eating habits have changed. My skin has cleared up recently but I can’t entirely put that down to the pill as I’ve changed the skincare products I’m using as well. Other than the bleeding I've felt completely fine, the bleeding (not the one just described) is just annoying more than anything.


Improved skin

1 more effect

0 helpful

0 comments

Progestogen-only / Mini pill  
Used for 6 - 12 mo
21 years old
🇬🇧 UK
  •  1 day ago

Desogestrel pill  

Since starting this pill after changing from Yasmin my hair has been thinner, I have more hair loss, increased oily skin and acne and I've been noticing palpitations I don't know if this has happened to anyone else but I've been experiencing chest pain all over, and I notice when I stopped taking it for a few weeks that chest went away but I'm back on it again and the chest pain came back. It may not be related but it's something new for me being on this pill. Other than that it's not been horrible I haven't had as much cramping on this pill as I did with Yasmin and I don't get debilitating headaches either.


Somewhat negative mood

2 more effects

0 helpful

0 comments

Progestogen-only / Mini pill  
Used for 1 - 3 mo
19 years old
🇬🇧 UK
  •  5 days ago

Desogestrel pill  

I have only been using the minipill for a month but I am already feeling pretty strong side effects especially on my mood: crying for no reason, being very angry at times and very sad at others, overall depressed mood. I am probably going to finish the blister and switch to something else.


Very negative mood

1 more effect

0 helpful

0 comments

Progestogen-only / Mini pill  
Used for 1 - 3 mo
24 years old
🇬🇧 UK
  •  1 day ago

Desogestrel pill  

Day 1 - (14/10/24)- cramping in uterus but not like period cramps, felt more like movement down there. Day 2 - similar cramping to day 1. Day 3 - Similar cramping still (but less frequent/not as bad), increased discharge, slight pressure headache. Day 4 - Similar headache to previous day, increased discharge - no cramping at all. Day 5 - Headache on right side of head near the back (dull ache, like I was trying to fight off a migraine from starting) felt a bit spacey all day. Nausea and some different cramping to what I felt previously (like the warning sign period cramps I get before the big ones kick in) Day 6 - Same headache, nausea and spacey-ness. Found that I felt better after eating more frequently (which might make sense as to why people say they gain weight on the pill because if eating makes me feel better then I’m sure as hell going to do it) In the morning had similar cramps to day 5 but gone by evening. - Did spend the daytime out though so the headache could have been made worse by the fact I wasn’t drinking water as regularly as I usually would. Day 7 - Started the day without a headache but by lunchtime I had one again. This could be because I’d had a busy morning though and ate lunch later than usual. # Day 8 - Ok for most of the day but by the evening I felt so nauseous and headachey Day 9 - Felt down and low all day - boobs seem to hurt and feel bigger almost? Slight cramping. Day 10 - Really really low today - sore boobs Day 11 - Really sore boobs are cramping Day 17 - (30/10/24) - Been fine for most this week except I’ve had sore boobs. Yesterday I had a suspicious cramp and today I’ve had more and some spotting/pre-period blood. This would mean my period is starting on day 27/28 of my cycle not day 31-35 as usual. Day 18 - Period started, has a different consistency than usual. More mucusy? I’m really not sure how to describe it, slippery? I mean it makes sense since desogestrel thickens the mucus lining. Period cramps HURT and some clotting which I haven’t had for a couple of years. Nothing major though. Day 19 - Same as yesterday. Not an extremely heavy period where I’m constantly having to change pads but I can tell this is heavy. Still that new consistency but occasionally the usual consistency. Not as bloody as usual. Day 20 - (2/11/24) - Medium-light flow. Usual consistency like I would be coming towards the endings of my usual period. (which usually lasts about 5 days) 4/12/24 - Not sure what to say the day is. I’ve had a lot of spotting this past month and basically haven’t been a day without wearing a period pad just in case.I had a mini proper period (not spotting) last week and I’m having another proper period now. It’s a lot and I just want to be able to not wear a pad anymore. I’m going to go back to the doctor this week to tell them about what's happening and get another prescription. 21/01/24 - I have no idea what day this would be now. (I’m into my 2nd week of my 4th month) I’ve been pretty much consistently bleeding all of December. Very light with a heavier week but not like my usual period and not the same cramping/minimal cramping. I think I’ve possibly gone 2 days without wearing a pad since I last wrote. However, I did completely stop bleeding for about 3 days last week which was lovely but then I had a proper period with cramps that hurt (well more like my periods pre-pill) It seems to be slowly stopping now though. I’ve gained a bit of weight (but not gone up a dress size) but this could be because I have been less active recently and my eating habits have changed. My skin has cleared up recently but I can’t entirely put that down to the pill as I’ve changed the skincare products I’m using as well. Other than the bleeding I've felt completely fine, the bleeding (not the one just described) is just annoying more than anything.


Improved skin

1 more effect

0 helpful

0 comments

Progestogen-only / Mini pill  
Used for 6 - 12 mo
21 years old
🇬🇧 UK
  •  1 day ago

Desogestrel pill  

Since starting this pill after changing from Yasmin my hair has been thinner, I have more hair loss, increased oily skin and acne and I've been noticing palpitations I don't know if this has happened to anyone else but I've been experiencing chest pain all over, and I notice when I stopped taking it for a few weeks that chest went away but I'm back on it again and the chest pain came back. It may not be related but it's something new for me being on this pill. Other than that it's not been horrible I haven't had as much cramping on this pill as I did with Yasmin and I don't get debilitating headaches either.


Somewhat negative mood

2 more effects

0 helpful

0 comments

Progestogen-only / Mini pill  
Used for 1 - 3 mo
19 years old
🇬🇧 UK
  •  5 days ago

Desogestrel pill  

I have only been using the minipill for a month but I am already feeling pretty strong side effects especially on my mood: crying for no reason, being very angry at times and very sad at others, overall depressed mood. I am probably going to finish the blister and switch to something else.


Very negative mood

1 more effect

0 helpful

0 comments

Progestogen-only / Mini pill  
Used for 12 - 18 mo
33 years old
🇬🇧 UK
  •  6 days ago

Desogestrel pill  

Please do NOT go on this. Not only did this give me severe Anxiety, Depression and Mood Swings, but I had many Dr and Hospital trips due to Panic Attacks, Migraines, Double Vision & Heart Palpitations. It was so bad, I had to get checked for suspected blood clot. A very scary experience. I hated every moment I was on this.


Very negative mood

2 more effects

0 helpful

0 comments

Progestogen-only / Mini pill  
Used for 3 - 6 mo
40 years old
🇬🇧 UK
  •  3 weeks ago

Desogestrel pill  

I got this pill after being 25 years on Yasmin but started to get headaches and turned 40 so was made to switch to Desogestrel. I didn't get headaches but everything else just got bad, was told to stay on it 6 months to get adjusted but after 5 and half months I finish the pack half way as I was getting really frustrated with it all. The side effects have been horrible - oily skin, scalp and nails, acne, hair loss and hair thinning, random spotting and I gained 15kg, I have never been so huge! I just hope all will return to normal soon as it's been very depressing.


Worse skin

1 more effect

1 helpful

1 comments

Progestogen-only / Mini pill  
Used for 6 - 12 mo
Lowdown user
🇬🇧 UK
  •  4th Nov 24

Desogestrel pill  

I started the POP because I had a few migraines with auras on the combined pill and had to stop this. When I started the mini-pill my periods became very irregular. However, I went on the combined pill in the first place because of my irregular cycle so this may just be me. I have noticed my periods are lighter but I never had heavy periods anyway. I have had a few cases of spotting for 2-3weeks after getting my period but this hopefully seems to have settled now after 5/6 months and I get a 3-5 day light period. My skin flared up with bad hormonal acne about 3/4months after I started taking the POP and hasn’t gotten any better. Another reason why I went on the combined pill initially was to help with acne so I feel this has regressed since starting the mini-pill. Also, I have had some horrific cramping at random times. A couple of times has been a whole week of painful cramps but again this hopefully seems to have settled down a bit after about 7/8 months of taking the POP. Overall, I’m not happy with the side effects I’m experiencing, especially my skin, and am considering trying the hormonal coil, but will give it a full year on the POP to see if my body starts to settle.


Somewhat negative mood

1 more effect

2 helpful

0 comments

Progestogen-only / Mini pill  
Used for 6 - 12 mo
Lowdown user
🇬🇧 UK
  •  31st Oct 24

Desogestrel pill  

I really wanted to like Desogestrel. Initially, my skin was the worst - so oily and immediately broke out in painful acne. This quickly subsided after about 2 weeks. For 3 months, my breasts were so enlarged and sore all the time. I noticed around the 3 month mark that I was experiencing vaginal dryness too. My periods have been totally irregular - since starting Desogestrel in May I've had 10 periods. Many of these were trigged by intercourse. The volume of blood and the level of pain was variable for every period, making it hard to predict. The final straw for me was I started losing my hair around the 5-6 month mark. My hair is noticeably thinner on top and the ends are ruined / look awful. The only positive for me has been that it made me more energetic and have a better / more even mood. It did has not affected my sex drive and I gained a negligible amount of weight.


Somewhat positive mood

2 more effects

2 helpful

1 comments

Progestogen-only / Mini pill  
Used for 1 - 3 mo
Lowdown user
🇬🇧 UK
  •  20th Oct 24

Desogestrel pill  

I was prescribed generic Desogestrel mini pill to treat my adenomyosis. I was only on it for a couple of weeks, but I couldn't cope with the symptoms. Daily bleeding and bloating but more worryingly, horrendous nausea, dizziness and migraines. Also had swollen tender enlarged breasts.


Very negative mood

1 more effect

2 helpful

0 comments

Progestogen-only / Mini pill  
Used for 1 - 3 mo
Lowdown user
🇬🇧 UK
  •  14th Oct 24

Desogestrel pill  

This desogestrol progesterone only pill was recommended to me during a specialist appointment for severe Menorrhagia, I also have endometriosis. On the first day of taking I did not notice any symptoms, on the second day my whole abdomen from side to side became painful, tender and swollen, same on day three and four progressively becoming worse. On day three and four I was getting pins and needles in both my hands intermittently. I felt nauseous on day two, three and four (this became constant from day three to four) and had some dizzy spells on both days too. I also experienced tender breasts from day 1 to 4. I exercise well everyday and noticed I was sweating more than usual and breathless after exertion, a lot more than usual. My sex drive changed because of the side effects I think. I stopped taking this medication after the fourth tablet because the side effects were so bad.


Somewhat negative mood

1 helpful

0 comments

Progestogen-only / Mini pill  
Used for 1 - 3 mo
Lowdown user
🇬🇧 UK
  •  10th Oct 24

Desogestrel pill  

Was put on this to help with my severe period pains. It has helped but I'm not sure it's worth it with the side effects. I can honestly say I am depressed. I have zero motivation, zero energy, zero inclination to do anything I used to enjoy. My sex drive has disappeared it doesn't matter because I've bled for the majority of the time I've been taking it. I want to stop but my GP won't try me on anything else until I've been on this for 3 months.


Somewhat negative mood

2 more effects

0 helpful

0 comments

Contraceptive alternatives and comparisons

Compare the Zelleta pill with other contraceptives

Compare the Desogestrel pill with other contraceptives

Order online

Order online now

Use our online prescription in under 5 mins

  • No GP appointment needed

  • Free standard delivery

Speak to a doctor

Not sure yet? Speak to a doctor

Schedule an appointment now

87% of women are happier with their contraceptive choice after speaking with one of The Lowdown's doctors

The Lowdown Footer

Women's health, reviewed.

Get the best women’s health info in your inbox

You are signing up to receive The Lowdown's latest findings and news in women's health. Your data will be used in accordance with our Privacy & Cookie policy

Built by doctors and experts

Our tools are made by medical professionals for your peace of mind

Our website uses affiliate links and we may earn a small commission if you click on them